The aim of this study is to investigate the relation between self-efficacy, mental health status, perceived stress and acculturative stress level among international students who are currently studying in colleges and universities in Ireland. This research was based on a quantitative cross sectional and correlational study. Participants consisted of 75 (Female N=56, Male N=19) international students studying 8 different colleges and university in Ireland. Participants completed self-report questionnaire of Self efficacy, General Health Questionnaire (GHQ-12), Perceived Stress Scale, and Acculturative Stress Scale for International Student (ASSIS). Collected data was analysed using Independent t-tests and Pearson’s correlation, and one-way ANOVA. Overall, the result indicated that higher perceived stress, higher acculturative stress level. Finding of the current study revealed that there was significant difference on the level of acculturative stress between female and male. Also, the level of acculturative stress on non-EU students slightly higher than those EU students.