The aim of this study is to investigate previously neglected psychological benefits of chiropractic healthcare. A quasi-experimental, cross-sectional design compared a natural chiropractic group (N=46) with a general population control group (N=4S), for the dependent variables of perceived stress, psychological health related quality of life (PHRQOL) and health locus of control (LOC) dimensions. Statistically significant lower stress levels, higher PHRQOL indications and internal LOC associations were hypothesised for chiropractic attendees. Additionally, stress and PHRQOL correlation was expected, irrespective of participant group. Data was analysed using independent samples t-tests, two-way ANOV A and Pearson correlations. While stress and PHRQOL were found to be strongly negatively associated, statistically significant results were not obtained for other hypotheses. Methodological features are likely responsible for unsupportive results. Further studies should address these methodological issues.