The aim of this study is to examine the issue of mood and anxiety issues comorbidity in adults with Autism Spectrum Disorder (ASD). There were a total of 120 participants in this study. Participants were gathered through Aspire, the Asperger association of Ireland. Three tools were used, Depression Anxiety Stress Scales 21, Perceived Stress Scale and the Multidimensional Scale of Perceived Social Support. This study was a cross-sectional survey with closed questioning. it was found that those with Asperger’s Syndrome expressed higher levels of perceived stress, depression, anxiety and less social support than neurotypicals. It was found that those in therapy reported higher levels of perceived stress than those not in therapy. Results showed there was no significant difference in perceived stress or perceived social support between the sexes. These findings support prior research suggesting that Asperger’s Syndrome comes with an increased amount of stress, anxiety, depression and a decreased perception of social support in comparison to neurotypicals.