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dc.contributor.advisorRichardson, Leeen
dc.contributor.authorMahon, Conallen
dc.date.accessioned2013-05-22T14:04:31Z
dc.date.available2013-05-22T14:04:31Z
dc.date.issued2005
dc.identifier.citationMahon, C. (2005). An investigation of prefrontal cortical function in bipolar affective disorder patients , their 1st degree relatives and controls. Bachelors Final Year Project, Dublin Business School.en
dc.identifier.urihttp://hdl.handle.net/10788/724
dc.description.abstractBipolar Affective Disorder (BPAD) is a common psychiatric illness with evidence supporting a high degree of genetic vulnerability. Current research is continuing to focus towards discovering possible genetic markers for the disorder, which in turn, may help in the eradication of the neurobiological mechanisms in the future. Essentially, neurocognitive endophenotypes may prove to be candidate markers in BPAD. 15 bipolar affective type 1 patients and 25 of their first-degree relatives were recruited from the St. Patrick's Hospital Bipolar Disorder Project in Dublin, Ireland. Global intelligence was measured in all individuals using the Wechsler Adult Intelligence Scale - Revised (WAIS-R). Executive function was assessed by using two psychometric tests. The tests used were the Wisconsin Card Sorting Test (WCST) and the Hayling Sentence Completion Task (HSCT). Normative data from the project database was used as controls. Relatives outperformed both controls and patients in the WCST. Controls were quicker than either relatives or patients in the HSCT, and patients had significantly more errors. Neurobiological correlates of the tests of executive function are discussed. Dorsal prefrontal function was found to be superior in relatives. Tests examining ventral prefrontal function showed dysfunction in the patient group while suggesting a more subtle dysfunction in the relative group. Ventral prefrontal cortical function may have potential as an endophenotypic marker for BPAD.en
dc.language.isoenen
dc.publisherDublin Business Schoolen
dc.rightsItems in Esource are protected by copyright. Previously published items are made available in accordance with the copyright policy of the publisher/copyright holder.en
dc.rights.urihttp://esource.dbs.ie/copyright
dc.subjectPsychologyen
dc.subjectPsychology, Pathologicalen
dc.subjectPeople with disabilitiesen
dc.titleAn investigation of prefrontal cortical function in bipolar affective disorder patients , their 1st degree relatives and controlsen
dc.typeFinal Year Projecten
dc.rights.holderCopyright: The authoren
dc.type.degreenameBA in Psychologyen
dc.type.degreelevelBAen


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