Awareness and filling-in of the human blind spot : linking Psychophysics with retinal topography

dc.contributor.authorMurphy, Jonathanen
dc.contributor.authorAbadi, Richard V.en
dc.contributor.authorJeffery, Glenen
dc.date.accessioned2014-03-03T12:23:19Z
dc.date.available2014-03-03T12:23:19Z
dc.date.issued2011
dc.description.abstractPurpose. To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. Methods. Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determine blind spot awareness and filling-in for five subjects. Histologic examination of six human retinas at 20-μm intervals from the temporal and nasal neural rims of the optic nerve head out to 1040 μm allowed the quantification of outer nuclear layer thickness, a direct correlate of photoreceptor density. Results. Blind spot awareness was reported for bar extensions beyond 0.4° to 0.8° from the edge of the blind spot. Partial and total blind spot filling-in were reported between 1.1° and 1.3° and beyond 1.5°, respectively. Histologic measures of ONL thickness were correlated with previously published data of photoreceptor spatial density to determine the percentage of photoreceptor density required to trigger a 75% probability response. Blind spot awareness was achieved by stimulating 43% to 70% of the maximum photoreceptor density. Partial and total filling-in of the blind spot required between 78% and 83% and more than 85% photoreceptor spatial densities, respectively. Conclusions. A novel intrinsic stimulus has been used to concurrently investigate blind spot awareness and blind spot filling-in. Retinal neural correlates of each visual experience have been quantified. Future computational models will have to integrate bottom-up constraints with long-range cortical receptive field activity and higher order cognitive factors.en
dc.description.versionPublished Versionen
dc.identifier.citationAbadi, Richard V., Jeffery, Glen & Murphy, Jonathan (2011). Awareness and Filling-in of the Human Blind Spot: Linking Psychophysics with Retinal Topography. Investigative Ophthalmology & Visual Science, 52(1), 541-548.en
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/10788/1673
dc.language.isoenen
dc.publisherInvestigative Ophthalmology & Visual Scienceen
dc.rightsItems in Esource are protected by copyright. Previously published items are made available in accordance with the copyright policy of the publisher/copyright holder.en
dc.rights.holderCopyright: The publisheren
dc.rights.urihttp://esource.dbs.ie/copyright
dc.source.urihttp://www.iovs.org/content/52/1/541.full#sec-5
dc.subjectPsychology
dc.titleAwareness and filling-in of the human blind spot : linking Psychophysics with retinal topographyen
dc.typeArticleen
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